NEW DRUGS 1999-2000
Generic Name |
Trade Name |
Company |
Approval |
Year |
Pharm/Chem Class |
Therapeutic |
Indication(s) |
Alitretinoin |
Panretin |
Ligand |
P/NME |
1999 |
Retinoid |
AIDS-Kaposi |
AIDS-related Kaposi's sarcoma |
Alosetron |
Lotronex |
Glaxo Wellcome |
|
2000 |
5-HT3 antagonist |
IBS |
IBS |
Aminolevulinic acid HCl |
Levulan Kerastick |
Guidelines |
NME |
1999 |
protoporphyrin IX Precursor |
Cancer |
precancerous skin lesions |
Amprenavir |
Agenerase |
Glaxo Wellcome |
P(6)/NME |
1999 |
Proteus Inhibitor |
AIDS |
HIV virus and AIDS |
Articaine HCl |
Septocaine |
Deproco |
|
2000 |
Anilide Anesthetic? |
Local Anesthetic |
Not used in US?!?!? |
Aspirin/Dipyridamole |
Aggrenox |
Boehringer-Ingelheim |
P/Combination |
1999 |
NSAID/ |
Stroke |
reduction of the risk of stroke |
Bexarotene |
Targretin |
Ligand |
NME/Orphan |
1999 |
Retinoid |
Cancer |
Cancer-CTLC |
BCG, Live |
Pacis |
BioChem Pharma |
|
2000 |
Bacillus Calmette-Guerin |
Cancer |
prostate and bladder cancer |
Busulfan |
Busulfex |
Orphan Med |
P |
1999 |
Alkylator |
Cancer |
bone marrow transplantation, |
Caffeine citrate |
Cafcit |
Oread Pediatric |
P/Combination |
1999 |
Xanthine |
Respiratory |
apnea of prematurity |
Cevimeline HCl |
Evoxac |
Snowbrand |
|
2000 |
Muscarinic Agonist |
Sjogren's Syndrome |
Improve Dry mouth |
Cilostazol |
Pletal |
Otsuka Pharm |
NME |
1999 |
PDE Inhibitor/Quinolinone |
Intermittent Claudication |
|
Colesevelam HCl |
Welchol |
Gel Tex |
NME |
2000 |
GI sequestrant |
Hypolipidemic |
elevated LDL-C with statin |
Cytarabine liposome |
Depocyt |
Depotech |
P |
1999 |
Nucleoside Antimetabolite |
Cancer |
neoplastic meningitis |
Dalfopristin/Quinupristin |
Synercid |
Rhone-Poulenc Rorer |
P/NME |
1999 |
Streptogramin |
Infection |
VRE-faecium |
Denileukin diftitox |
Ontak |
Seragen |
Orphan |
1999 |
diphtheria toxin to interleukin-2 (IL-2) |
Cancer |
Cancer-CTLC |
Dexmedetomidine HCl |
Precedex |
Abbott |
NME |
1999 |
Alpha-2 Agonist |
Sedation |
Intubated/mechanically ventilated Pts |
Dofetilide |
Tikosyn |
Pfizer |
NME |
1999 |
Class III |
Arrhythmias |
Convert Afib/Aflut to normal sinus rhythm |
Doxercalciferol |
Hectorol |
Bone Care |
NME |
1999 |
Vitamin D |
Secondary hyperparathyroidism (dialysis) |
Secondary hyperparathyroidism (dialysis) |
Entacapone |
Comtan |
Orion/Novartis |
NME |
1999 |
COMT Inhibitor |
Parkinsonism |
Adjunct with L-DOPA/carbidopa |
Epirubicin HCl |
Ellence |
Pharmacia&Upjohn |
P/NME/Orphan |
1999 |
Anthracycline |
Cancer |
Breast cancer: Axillary node tumor involvement post resection |
Estradiol/Norethindrone Acetate |
Activella |
Pharmacia |
|
2000 |
Hormones |
Osteoporosis |
Postmenopausal Osteoporosis |
Etanercept |
Enbrel |
Immunex Wyeth-Ayerst |
Orphan |
1999 |
TNF-IGG-1 Complex |
Arthritis |
polyarticular course juvenile rheumatoid arthritis |
Exemestane |
Aromasin |
Pharmacia&Upjohn |
NME |
1999 |
Aromatase Inhibitor |
Cancer |
advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy. |
Gadoversetamide |
Optimark |
Mallinckrodt |
NME |
1999 |
|
Imaging |
|
Ganirelix acetate |
Antagon |
Organon |
P(6)/NME |
1999 |
GnRH Antagonist. |
Infertility |
Inhibitor of premature ovulation: Fertility testing |
Gatifloxacin |
Tequin |
Bristol-Myers Squibb |
NME |
1999 |
Fluoroquinolone |
Infection |
Oral/IV: Respiratory/GU infections |
Gemtuzumab ozogamicin |
Mylotarg |
Wyeth-Ayerst |
Biologic |
2000 |
Monoclonal antibody |
Cancer |
CD33+ acute myeloid leukemia (AML) |
Human Insulin |
Velosulin |
Novo Nordisk |
|
1999 |
Insulin |
Diabetes |
|
Infliximab |
Remicade |
Centocor |
|
1999 |
monoclonal antibody |
Arthritis |
with methotrexate for the treatment of patients with rheumatoid arthritis |
Insulin glargine |
Lantus |
Aventis |
|
2000 |
Insulin Analogue |
Diabetes |
Type I Diabetes |
Ketotifen fumarate |
Zaditor |
Ciba Vision |
P(6)/NME |
1999 |
Histamine-1 antagonist |
Conjunctivitis |
Allergic disease |
Levetiracetam |
Keppra |
UCB Pharm |
NME |
1999 |
Mech Unknown |
Epilepsy |
partial onset seizures |
Levobupivacaine |
Chirocaine |
Darwin Disc |
P/Combination |
1999 |
Anesthesia/Pain |
|
|
Levonorgestrel |
Plan B |
Womens Capital |
P |
1999 |
synthetic progestin |
Contraception |
|
Linezolid |
Zyvox |
Pharmacia&Upjohn |
|
2000 |
oxazolidinone |
Infection |
Enterococcal (VRE) and Staph infections |
Meloxicam |
Mobic |
Boehringer-Ingelheim |
|
2000 |
NSAID/Oxicam |
Arthritis |
Osteoarthritis |
Mequinol/Tretinoin |
Solage |
Bristol-Myers Squibb |
NME |
1999 |
Hydroquinone/Retinoid |
Dermatologic |
Solar lentigines ("Liver spots") |
Moxifloxacin HCl |
Avelox |
Bayer |
NME |
1999 |
Fluoroquinolone |
Infection |
Respiratory infections |
Nedocromil sodium |
Alocril |
Allergan |
P |
1999 |
Cromolyn Analog |
Asthma |
|
Nitric oxide |
INOmax |
INO Therapeutics |
P/NME |
1999 |
Nitric Oxide |
Hypertension |
persistent pulmonary hypertension in the newborn |
Orlistat |
Xenical |
Roche |
P/NME |
1999 |
Lipase inhibitor |
Obesity |
Obesity |
Oseltamivir phosphate |
Tamiflu |
Roche |
P(6)/NME |
1999 |
Neuraminidase Inhibitor |
Influenza |
onset of influenza A and B |
Oxcarbazepine |
Trileptal |
Novartis |
|
2000 |
Carbamazepine Analog |
Epilepsy |
partial onset seizures |
Pantoprazole |
Protonix |
Wyeth-Ayerst |
|
2000 |
Proton Pump Inhibitor |
GERD |
Erosive Esophagitis assocaited with GERD |
Pemirolast potassium |
Alamast |
Santen |
P(6)/NME |
1999 |
Cromolyn Analog |
Conjunctivitis |
Allergic disease |
Pioglitazone HCl |
Actos |
Eli Lilly |
P(6)/NME |
1999 |
thiazolidinedione |
Diabetes II |
type II |
Pneumococcal Vaccine |
Prevnar |
Wyeth-Ayerst |
|
2000 |
Vaccine |
Infection |
prevent invasive pneumococcal diseases in |
Poractant alfa |
Curosurf |
Deys Labs |
NME |
1999 |
lung surfactant |
Respiratory |
infants and toddlers |
Rabeprazole sodium |
Aciphex |
Eisai |
NME |
1999 |
Proton Pump Inhibitor |
Ulcers |
Duodenal Ulcers |
Rapacuronium bromide |
Raplon |
Organon |
NME |
1999 |
NMBA |
Adjunct in surgery |
Adjunct in surgery |
Rivastigmine tartrate |
Exelon |
Novartis |
|
2000 |
ACHE Inhibitor |
Alzheimer's disease |
Alzheimer's disease |
Rofecoxib |
Vioxx |
Merck |
P(6)/NME |
1999 |
COX-2 Inhibitor |
Arthritis |
ostearthritis, menstrual pain and the management of acute pain in adults |
Rosiglitazone maleate |
Avandia |
SKBeecham |
P(6)/NME |
1999 |
thiazolidinedione |
Diabetes II |
type II |
Sirolimus |
Rapamune |
Wyeth-Ayerst |
P/NME |
1999 |
Immunosuppresant |
immunosuppressant |
prophylaxis: Organ rejection (Renal transplants) |
Sodium ferric gluconate |
Ferrlecit |
R&D Labs |
P/NME |
1999 |
Iron |
Iron Deficiency |
Pts undergoing chronic dialysis |
Somatropin (rDNA origin) |
Nutropin Depot |
Genentech |
P |
1999 |
recombinant growth hormone |
Growth |
long-term treatment of growth failure |
Technetium depreotide |
Neotect |
Diatide |
P/NME |
1999 |
|
Imaging |
|
Temozolomide |
Temodar |
Schering |
P/NME/Orphan |
1999 |
Imidazotetrazine Alkylator |
Cancer |
anaplastic astrocytoma (brain cancer) |
Tenecteplase |
TNKase |
Genentech |
Biologic |
2000 |
Enzyme |
Thrombolytic |
AMI |
testosterone gel |
AndroGel |
Unimed Pharm |
|
2000 |
Steroid: Androgen |
Steroid: Androgen |
hypogonadism |
Verteporfin |
Visudyne |
QLT Photother |
|
2000 |
|
|
age-related macular degeneration |
Zaleplon |
Sonata |
Wyeth-Ayerst |
NME |
1999 |
Pyrazolopyrimidine |
Insomnia |
GABA-A ligand: |
Zanamivir |
Relenza |
Glaxo Wellcome |
P/NME |
1999 |
Neuraminidase Inhibitor |
Influenza |
influenza |
Zonisamide |
Zonegran |
Elan Pharm |
|
2000 |
"Valphenytoin" |
Epilepsy |
partial onset seizures |