Pathology and Pathogenesis (page 395)

• Chronic vs Acute renal failure pathogenesis:

  • Acute: tubular cell death and regeneration (reversible)
  • Chronic: Irreversible nephron loss

• Glomerular Hyperfiltration:

  • Compensatory mechanism with increased nephron GFR:
  • Pre-disposition to glomerular sclerosis

• Azotemia at 30-35% GFR

• Uremia: ង% normal excretory capacity

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