GLOMERULONEPHRITIS: Clinical manifestations (pages 400-401)
Proteinuria and hematuria: Damage to capillary wall allows “leakage”
Decreased GFR:
- Infiltration of glomerular capillaries with inflammatory cells, OR
- Expansion of contractile mesangial cells
Edema and Hypertension: Fluid and salt overload from decreased GFR
Transient decrease in serum complement
Transient elevations antibody to streptococcal antigen