Rapidly Progressive Glomerulonephritis(pages 398 & 400)

• Clinical Presentation: “Intermediate” stage

  • Failure to recover from Acute Glomerulonephritis: Origin unknown
  • Worsening renal function with irreversible and complete renal failure a the outcome

• Pathology & Pathogenesis

  • Intermediate stage between “Acute” and “Chronic”
  • Extracapillary cellular proliferation: 70% of glomeruli
  • Basement membrane gap/discontinuities
  • Deposition of anti-GBM antibodies or granular immunoglobulins

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