Selected Publications
2023
Jun L, Robinson M, Geetha T, Broderick TL, Babu JR. Prevalance and mechanisms of skeletal muscle atrophy in metabolic conditions. International Journal of Molecular Sciences 2023; 24: 2973. doi: 10.3390/ijms24032973.
Richter E, Geetha T, Burnett D,Broderick TL, Babu JR. The effects of momordica charantia on type 2 diabetes mellitus and Alzheimer's Disease. International Journal of Molecular Sciences 2023; 24: 4643. doi: 10.3390/ijms24054643.
Knight E, Geetha T, Broderick TL, Babu JR. The role of dietary antioxidants and their potential mechanisms in Akzheimer's disese treatment. Metabolites 2023; 2023: 438.10.3390/metabo13030438.
Oyerinde AS, Selvaraju V, Babu JR, Geetha T. Potential role of oxidative stress in the production of volatile organic compounds in obesity. Antioxidants (Basel) 2023; 12: 129.doi: 10.3390/antiox12010129.
Patel P, Selvaraju V, Babu JR, Wang X, Geetha T. Novel differntially methylated regions identified by genome wide DNA methylationanalyses contribute to racial disparities in childhood obesity. Genes (Basel) 2023; 14:1098. doi: 10.3390/genes14051098.
Key J, Burnett D, Babu JR, Geetha T. The effectcts of food environment on obesity in children: A systematic review. Children 2023; 10: 98.doi: 10.3390/children10010098.
2022
Knight E, Geetha T, Burnett D, Babu JR. The role of diet and dietary patterns in Parkinson's Disease. Nutrients 2022; 14: 4472.doi: 10.3390/nu14214472.
Li R, Ding X, Geetha T, Fadamiro M, St Aubin CR, Shim M, Al-Nakkash L, Broderick TL, Babu JR. Effects of genistein and exercise training on brain damage induced by a high-fat high-sucrose diet in female C57BL/6 mice. Oxidative Medicine and Cellular Longevity 2022; 2022: 1560435.doi: 10.1155/2022/1560435.
Li Y, Lai W, Zheng C, Babu JR, Xue Cm Ai Q, Huggins KW. Neuroprotective effect of stearidonic acid on amyloid beta induced neurotoxicity in rat hippocampal cells. Antioxidants (Basel) 2022; 11:2357. doi: 10.3390/antiox11122357.
Patel P, Selvaraju V, Babu JR, Wang X, Geetha T. Racial disparities in methylation of NRF1, FTO, and LEPR gene in childhood obesity. Genes (Basel) 2022; 13:2030. doi: 10.3390/genes13112030.
Selvaraju V, Babu JR, Geetha T. Salivary neurotrophins brain derived neurotrophic factor and nerve growth factor associated with childhood obesity: A multiplex magnetic luminescence analysis. Diagnostics (Basel) 2022;3;12(5):1130. doi: 10.3390/diagnostics12051130.
Li R, Robinson M, Ding X, Geetha T, Al-Nakkash L, Broderick TL, Babu JR. Genistein: A focus on several neurodegenerative diseases. Journal of Food Biochemistry 2022;e14155. doi: 10.1111/jfbc.14155. Online ahead of print.
Kothari V, Babu JR, Mathews ST. AMP activated kinase negatively regulates hepatic Fetuin- A via p38 MAPK-C/EBPB/E3 ubiquitin ligase signaling pathway. PLoS One 2022;6;17(5):e0266472. doi: 10.1371/journal.pone.0266472. eCollection 2022.
Selvaraju V, Babu JR, Geetha T. Multiflexed measurements of salivary fetuin-A, insulin, and adiponectin as potential non-invasive biomarkers in childhood obesity. Cytokine 2022; 153:155843. doi: 10.1016/j.cyto.2022.155843.
Patel P, Babu JR, Wang Xu, Geetha T. Role of macronutrient intake in the epigenetics of obesity. Biochemical Society Transactions 2022; 50:487-497. doi: 10.1042/BST20211069.
2021
Ding XW, Robinson M, Li R, Aldhowayan H, Geetha T, Babu JR. Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer's disease. Pharmacological Research 2021;171:105783.doi: 10.1016/j.phrs.2021.
Smith K, Greene M, Babu JR, Fruge A. Psychobiotics as treatment for anxiety, depression, and related symptoms: a systemic review. Nutritional Neuroscience 2021;24:963-977
Phillips M, Selvaraju V, Fouty A, Babu JR, Sandey M, Geetha T. High Olfactory Receptor-Rich 11q11 Copy Number in Girls and African American Children. Genes (Basel) 2021;12:1943.
Balakrishnan B, Selvaraju V, Chen J, Ayine P, Yang L, Babu JR, Geetha T, Taneja V. Ethnic variability associating gut and oral microbiome with obesity in children. Gut Microbes 2021;13:1-15.
Riviere AJ,Leach R, Mann H, Robinson S, Burnett DO, Babu JR, Frugé AD. Nutrition knowledge of collegiate athletes in the United States and the impact of sprotes dieticians on related outcomes: A narrative review. Nutrients 2021; 13:1772.doi: 10.3390/nu13061772.
Selvaraju V, Megan P, Forty A, Babu JR, Geetha T. Telomere length as a biomarker for race-related health disparities. Genes(Basel) 2021; 9:78.doi: 10.3390/genes12010078
2020
Broderick TL, Rasool S, Li R, Zhang Y, Anderson M, Al-Nakkash L, Plochocki JH, Geetha T, Babu JR. Neuroprotective effects of chronic resveratrol treatment and exercise training in the 3XTg-AD mouse model of Alzheimer's disese. International Journal of Molecular Sciences 2020;21:7337-7358.
Ding XW, Li R, Geetha T, Tao YX, Babu JR. Nerve growth factor in metabolic complications and Alzheimer's disease: Physiology and therapeutic potential. Biochim Biophys Acta 2020;1866:165858-165870.
Phillips M, Babu JR, Wang X, Geetha T. DNA copy number and strutural variation (CNV) contributions to adult and childhood obesity. Biochemical Society Transactions 2020;48:1819-1828.
Li R, Ding XW, Geetha T, Al Nakkash L, Broderick TL, Babu JR. Beneficial effects of genistein on diabetes-induced brain damage in the ob/ob mouse model. Drug Design, Development and Therapy 2020;14:3325-3336.
Williams A, Babu JR, Wadsworth D, Burnett D, Geetha T. The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review. Hormone and Metabolic Research 2020;52:485-491.
Selvaraju V, Venkatpoorna C, Babu JR, Geetha T. Salivary Amylase Gene Copy Number is Associated with the Obesity and Inflammatory Markers in Children. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020;13:1695-1701.
Venkatpoorna C, Ayine P, Selvaraju V, Parra P, Koenigs T, Babu JR, Geetha T. The realationship between obesity timing behavior, television exposure, and dinnertime anoung elementary school-age children. Journal of Clinical Sleep Medicine 2020;16: 129-136.
2019
Vines K, Li R, Geetha T, Broderick T, Babu JR. Nerve growth factor receptor TrKA signaling in streptozotocin- induced type 1 diabetes rat brain. Biochemical and Biophysical Research Communications 2019;514:1285-1289.
Sycheva M, Sustarich J, Zhang Y, Selvaraju V, Geetha T, Babu JR. Pro-nerve growth factor induces activation of RhoA kinase and neuronal cell death. Brain Sciences 2019; Aug 19;9(8):204. doi: 10.3390/brainsci9080204.
Selvaraju V, Ayine P, Fadamiro M, Selvaraju V, Babu JR, Brown M, Geetha T. Urinary biomarkers of inflammation and oxidative stress are elevated in obese children and correlate with a marker of endothelial dysfunction. Oxidative Medicine and Cellular Longevity 2019; Oct 16;2019:9604740. doi: 10.1155/2019/9604740. eCollection 2019.
Selvaraju V, Babu JR, Geetha T. Association of salivery C-reactive protein with the obesity measures and markers in children. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019; 12:1239-1247.
Venkatpoorna C, Ayine P, Parra P, Koenigs T, Phillips M, Babu JR, Sandey M, Geetha T. Association of salivary amylase (AMY1) gene copy number with obesity in Alabama elementary school children. Nutrients 2019;doi: 10.3390/nu11061379.
Smith KS, Greene MW, Babu JR, Fruge AD. Psychobiotics as treatment for anxiety, depression, and related symptoms: a systematic review. Nutritional Neuroscience 2019;Dec 20:1-15. doi: 10.1080/1028415X.2019.1701220.
Chester B, Babu JR, Greene MW, Geetha T. The effects of popular diets on Type 2 Diabetes Management. Diabetes Metabolism Research and Reviews 2019;doi: 10.1002/dmrr.3188.
Li R, Zhang Y, Rasool S, Geetha T, Babu JR. Effects and underlying mechanisms of bioactive compounds on type 2 diabetes mellitus and alzheimer's disease. Oxidative Medicine and Cellular Longevity 2019;2019:1-25.https://doi.org/10.1155/2019/8165707
Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschunk GD, Broderick TL. Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer's disease. Drug Design, Development and Therapy 2019;17;13:1197-1211.
Alkhouli MF,Hung J, Squire M, Anderson M, Catro M,Babu JR, Al-Nakkash L, Broderick TL, PloChocki JH. Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease. BMC Complementary and Alternative Medicine 2019;19:39.doi: 10.1186/s12906-019-2451-6.
2018
Rasool S, Geetha T, Broderick TL, Babu JR. High fat with high sucrose diet leads to obesity and induces myodegeneration. Frontiers in Physiology 2018;9:1-10.
Broderick TL, Cusimano FA, Carlson C, Babu JR. Biosynthesis of the essential fatty acid oxidation cofactor carnitine is stimulated in heart and liver after a single bout of exercise in mice. Journal of Nutrition and Metabolism 2018;2018:1-7.
Rodick T, Seibels D, Babu JR, Huggins KW, Ren G, Mathews ST. Potential role of coenzyme Q10 in health and disease conditions. Nutrition and Dietary Supplements 2018;10:1-11.
2017
Li Y, Rong Y, Bao L, Nie B, Ren G, Zheng C, Amin R, Arnold RD, Babu JR, Huggins KW. Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells. Lipids in Health and Disease 2017;16:181-191.
Kothari V, Luo Y, Tornabene T, O'Neill AM, Greene MW, Geetha T, Babu JR. High fat diet induces brain insulin resistance and cognitive impairement in mice. Biochim Biophys Acta 2017;1863:499-508.
Rege SD, Geetha T, Broderick TL, Babu JR. Can diet and physical activity limit Alzheimer's disease risk? Current Alzheimer Research 2017;14:76-93.
2016
Neidert LE, Waninright KS, Zheng C, Babu JR, Kluess HA. Plasma dipeptidyl peptidase IV activity and measures of body composition in apparently healthy people. Heliyon 2016; 2:e00097. doi:10.1016/j.heliyon.2016.e00097.
Wilson DN, Schacht SE, Nakkash LA, Babu JR, Broderick TL. Resveratrol prevents pulmonary trunk remodeling but not right ventricular hypertrophy in monocrotaline- induced pulmonary hypertension. Pathophysiology 2016: May.27. doi:10.1016/j.pathophys.2016.05.004
2015
Zheng C, Geetha T, Gearing M, Babu JR. Amyloid beta abrogated TrkA ubiquitination in PC12 cells analogous to Alzheimer's disease. Journal of Neurochemistry 2015;6:919-925.
Rege SD, Geetha T, Broderick TL, Babu JR. Resveratrol Protects beta amyloid-Induced Oxidative Damage and Memory Associated Proteins in H19-7 Hippocampal Neuronal Cells. Current Alzheimer Research 2015;12(2):147-156.
Pondugula SR, Flannery PC, Apte U, Babu JR, Geetha T, Rege SD, Chen T, Abbott KL. PPM1A phosphatase is involved in regulating PXR-mediated CYP3A4 gene expression. Drug Metabolism and Disposition 2015;3:385-391.
2014
Zheng C, Geetha T, Babu JR. Failure of ubiquitin proteasome system: Risk for neurodegenerative diseases. Neurodegenerative Diseases 2014;14:161-175.
Brust KB, Corbell KA, Al-Nakkash L, Babu JR, Broderick TL. Expression of gluconeogenic enzymes and 11beta-HSD type 1 in liver of diabetic mice after acute exercise. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014;7:495-504.
Rege SD, Geetha T, Griffin GD, Broderick TL, Babu JR. Neuroprotective effects of resveratrol in Alzheimer disease pathology. Frontiers in Aging Neuroscience 2014: doi: 10.3389/fnagi.2014.00218.
Desai G, Zheng C, Geetha T, Mathews ST, White BD, Huggins KW, Zizza CA, Broderick TL, Babu JR. The pancreas-brain axis: insight into disrupted mechanisms associating type 2 diabetes and Alzheimer disease. Journal of Alzheimer's Disease 2014;42:347-356.
2013
Rege SD, Kumar S, Wilson D, Tamura L, Geetha T, Mathews ST, Huggins KW, Broderick TL, Babu JR. Resveratrol protects the brain of obese mice from oxidative damage. Oxidative Medicine and Cellular Longevity 2013; 2013: 419092.doi: 10.1155/2013/419092.
Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR. Nerve growth factor Receptor TrKA, a new receptor in insulin signaling pathway in PC12 cells. Journal of Biological Chemistry 2013; 288: 23807-23813.
Rege SD, Geetha T, Pondugula S, Zizza C, Wernette C, Babu JR. Non-coding RNAs in Neurodegenerative Diseases. ISRN Neurology 2013 Apr 30; 2013:375852. doi: 10.1155/2013/375852. 2012; 287:29672-29678.
2012
Geetha T, Zheng C, McGregor WC, White DB, Diaz-Meco MT, Babu JR. TRAF6 and p62 inhibit amyloid beta-induced neuronal death through p75 neurotrophin receptor. Neurochemistry International 2012; 61: 1289-1293. 2012; 421:286-290.
Geetha T, Zheng C, Vishwaprakash N, Broderick TL, Babu JR. Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1. Journal of Biological Chemistry 2012; 287: 29672-29678.
Geetha T, Zheng C, Unroe B, Sycheva M, Kluess H, Babu JR. Polyubiquitination of the neurotrophin receptor p75 directs neuronal cell survival. Biochemical and Biophysical Research Communications. 2012; 421: 286-290.
Geetha T, Vishwaprakash N, Sycheva M, Babu JR. Sequestosome 1/p62: Across diseases.Biomarkers. 2012; 17: 99-103.
Published before 2012
Diarra A, Geetha T, Potter P, Babu JR. Signaling of the neurotrophin receptor p75 in relation to Alzheimer's Disease. Biochemical and Biophysical Research Communications. 2009; 390: 352-356.
Babu JR, Seibenhener ML, Peng J, Stroem AL, Kemppainen R, Cox N, Zhu H, Wooten M, Diaz-Meco MT, Moscat J. Wooten MW. Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. Journal of Neurochemistry 2008; 106: 107-120.
Wooten MW, Geetha T, Babu JR, Seibenhener ML, Peng J, Cox N, Diaz-Meco MT, Moscat J. Essential role of SQSTM1/p62 in regulating accumulation of K63-ubiquitinated proteins. Journal of Biological Chemistry. 2008; 283: 6783-6789.
Zhou X#, Babu JR#, Silva S, Shu Q, Graef I, Oliver T, Tomoda T, Tani T, Wooten MW, and Wang, F. Unc-51-like kinase ½- mediated endocytic process regulate NGF signaling and filopodia extension in sensory axons. Proceedings of the National Academy of sciences 2007; 104: 5842-5847. (# Equal Contribution)
Wooten MW, Hu X, Babu JR, Seibenhener, ML, Geetha T, Paine MG, and Wooten MC. Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease. Journal of Biomedicine and Biotechnology 2006; 62079-62096. (Invited Review Article - 18 pages)
Paine MG, Babu JR, Seibenhener ML, and Wooten MW. Evidence for p62 aggregate formation: role in cell survival. FEBS Letters 2005; 579: 5029-5034.
Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, and Moscat J. The p62 scaffold regulates nerve growth factor-induced NF-kappa B activation by influencing TRAF6 polyubiquitination. Journal of Biological Chemistry 2005; 280: 35625-35629.
Babu JR, Geetha T, Wooten MW. Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation. Journal of Neurochemistry 2005; 94: 192-203.
Seibenhener ML, Babu JR, Geetha T, Wong H, Krishna NR, Wooten MW. Sequestosome/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasomal degradation. Molecular and Cellular Biology 2004; 24: 8055-8068.
Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential checkpoint regulator that cooperates with Bub3 to prevent missegregation. Journal of Cell Biology 2003; 160: 341-353.
Editorial text http://www.jcb.org/cgi/content/full/160/3/284-aWang X, Babu JR, Harden JM, Jablonski SA, Gazi MH, Lingle WL, de Groen PC, Yen TJ, van Deursen JM. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. Journal of Biological Chemistry 2001; 276: 26559-26567.
Publications in the name of Jeganathan Ramesh Babu