ACUTE RENAL FAILURE:Pathology (pages 390-392)

• Acute tubular necrosis (ATN):

  • Tubular cell sloughing
  • Reversibility/Irreversibility: Dependent on time of intervention

• ATN Pathogenesis

  • Tubular occlusion theory and cast formation
  • Vascular hypoperfusion theory: Afferent vasoconstriction with Efferent vasodilation
  • Role of renal mediators?

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