ACUTE RENAL FAILURE:Early Clinical Manifestations (pages 392-394)

• Symptoms depend on degree and cause of renal failure (See Table 16-5)

• Initial Symptoms: Fatigue and malaise:

  • Loss of excretory capacity and accumulation of water, electrolytes and nitrogenous wastes
  • Prerenal azotemia: Elevated BUN/SrCr (20-30:1) with normal SrCr
  • Urinalysis: No casts detected
  • Maximal urinary concentration: 1500 mosm/L
  • Fractional Na Excretion (99%)
  • May progress to ATN without proper treatment

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